Technical Overview of HPLC Columns for Reducing Solvent Use and Waste

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Technical Overview of HPLC Columns for Reducing Solvent Use and Waste

Post by Wilson DeCastro on Wed May 06, 2009 5:45 pm

Acetonitrile is the most versatile and commonly used solvent in HPLC, but it is currently in critically short supply. Laboratories can realize a 40-90% reduction in acetonitrile usage by changing the HPLC column while keeping the same bonded phase. Possibilities include reduction of the diameter of the column, a change to a shorter column with a smaller particles size, or a simultaneous reduction of length, diameter, and particle size. These options are easy to implement, do not require redevelopment of the method, and in some cases significantly reduce the analysis time. This Technical Overview discusses these opportunities and considers how to balance reduction of solvent use with regulatory requirements and thedesire to use conventional LC instrumentation...

Go to http://www.chem.agilent.com/Library/technicaloverviews/Public/5990-3972EN.pdf for a copy of the technical overview,

or

coordinate with your DKSH key persons.

Thanks,
Wilson

Wilson DeCastro
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